Our friends over at Nature have produced a vidoe that explains the ENCODE project at a 101 level. Bradley Bernstein’s lab at the Broad Institute, which specializea in high-throughput sequencing-based technologies, handled the local piece of the multi-site project. (FYI: Broad rhymes with ENCODE.)
Though much of what defines a human is encoded in the sequence of our DNA, many additional factors influence how this genetic information is manifest. For example, heritable epigenetic information contained within chromatin, the higher-order structure that packages the genome, has critical functions during embryonic development and can contribute to the pathogenesis of disease.